7SL RNA Is Retained in HIV-1 Minimal Virus-Like Particles as an S-Domain Fragment

Role of HIV-1 RNA and protein determinants for the selective packaging of spliced and unspliced viral RNA and host U6 and 7SL RNA in virus particles

HIV-1 particles contain RNA species other than the unspliced viral RNA genome. For instance, viral spliced RNAs and host 7SL and U6 RNAs are natural components that are non-randomly incorporated. To understand the mechanism of packaging selectivity, we analyzed the content of a large panel of HIV-1 variants mutated either in the 5'UTR structures of the viral RNA or in the Gag-nucleocapsid prote...

The genomic RNA in Ty1 virus-like particles is dimeric.

The yeast retrotransposon Ty1 resembles retroviruses in a number of important respects but also shows several fundamental differences from them. We now report that, as in retroviruses, the genomic RNA in Ty1 virus-like particles is dimeric. The Ty1 dimers also resemble retroviral dimers in that they are stabilized during the proteolytic maturation of the particle. The stabilization of the dimer...

Virus-like particles as vaccine.

This review presents data on commercial and experimental virus-like particle (VLP) vaccines, including description of VLP vaccines against influenza. Virus-like particles are multimeric, sometimes multiprotein nanostructures assembled from viral structural proteins and are devoid of any genetic material. VLPs present repetitive high-density displays of viral surface proteins. Importantly, they ...

Avian lymphoid leukosis: Virus-like particles in kidney Cells

HIV - 1 Virus Like Particles Produced by Stably Transfected 1 Drosophila S 2 cells - a Desirable Vaccine Component

22 The development of a successful vaccine against HIV-1 likely requires 23 immunogens that elicit both broadly neutralizing antibodies against envelope 24 spikes and T cell responses that recognize multiple viral proteins. HIV-1 virus like 25 particles (VLP), because they display authentic envelope spikes on the particle 26 surface, may be developed into such immunogens. However, in one way or...